|aPart I: An overview of cell signalling -- Aspects of cellular signalling -- Pathways are the key to signalling -- A look at some of the history and techniques of cell signalling -- Part II: Components that comprise signalling pathways -- Extracellular signals: hormones, cytokines and growth factors -- Detection of extracellular signals: the role of receptors -- Protein Phosphorylation, kinases and phosphatases -- Cyclic nucleotides, cyclases and G proteins -- Inositol phosphate metabolism and roles of membrane lipids -- Intracellular calcium: Its control and role as an intracellular signal -- Reactive oxygen species, reactive nitrogen species and redox signalling -- Part III: Selected examples of signalling pathways and events -- Insulin and the signal transduction cascades it invokes -- Perception of the environment -- Signalling in development and for the regulation of gene expression -- Life, death and apoptosis -- Part IV: Final thoughts -- Cell Signalling: importance, complexity, and future Index.
|a'Cell Signalling' presents a carefully structured introduction to this subject, introducing those conserved features which underlie many different extra-and intracellular signalling systems.
Signalling within and between cells is an essential part of many biological processes, from the development of the body to the activity of our immune system. Cell Signalling, Third Edition, presents a carefully structured introduction to this intricate subject, introducing those conserved features that underlie many different extra- and intracellular signalling systems. Starting with an overview of cell signalling and highlighting its importance in many biological systems, the book goes on to explore the key components of extracellular and intracellular signalling mechanisms before examining how these components come together to create signalling pathways, which are so crucial to the survival of many living organisms. The text is enhanced by two-color artwork and 3-D protein models. A Companion Website provides resources for students and instructors. New to this edition: * Expanded coverage of the role of cell signalling during development, experimental techniques, and the control of gene expression * New "Literature Links" encourage students to engage with primary literature and to develop critical thinking and reading skills * New four-part structure organizes the subject according to its conceptual basis, the mechanisms of signalling, and their role in natural phenomena