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Evaluation of enzyme inhibitors in drug discovery : a guide for medicinal chemists and pharmacologists /

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008		081224s2005 njua b 001 0 eng
010		\|a 2004023470
020		\|a0471686964 (cloth)
020		\|a9780471686965 (cloth)
035		\|a(OCoLC)56793559 \|z(OCoLC)60512070\|z(OCoLC)60792483
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042		\|apcc
050	00	\|aQP601.5\|b.C675 2005
060	00	\|aW1\|bME9617 v.46 2005
060	10	\|aQU 143\|bC782e 2005
070	0	\|a381\|bM55 v. 46
092		\|a615.19\|bC79
095		\|pBOOK\|d615.19\|eC79
100	1	\|aCopeland, Robert Allen.
245	10	\|aEvaluation of enzyme inhibitors in drug discovery :\|ba guide for medicinal chemists and pharmacologists /\|cRobert A. Copeland.
260		\|aHoboken, N.J. :\|bWiley-Interscience,\|c2005.
300		\|axvii, 271 p. :\|bill. ;\|c25 cm.
440	0	\|aMethods of biochemical analysis ;\|vv. 46
504		\|aIncludes bibliographical references and index.
505	0	\|aWhy enzymes as drug targets? -- Enzyme reaction mechanisms. -- Reversible modes of inhibitor interactions with enzymes. -- Assay considerations for compound library screening. -- Lead organization and structure-activity relationships for reversible inhibitors. -- Slow binding inhibitors. -- Tight binding inhibitors. -- Irreversible enzyme inactivators. -- Appendix 1. Kinetics if biochemical reactions. -- Appendix 2. Derivation of the enzyme-ligand binding isotherm equation. -- Appendix 3. Serial dilution schemes.
650	0	\|aEnzyme inhibitors\|xTherapeutic use\|xTesting.
650	0	\|aDrugs\|xDesign.
650	0	\|aEnzyme inhibitors\|xStructure-activity relationships.
650	17	\|aEnzyminhibitoren.\|2gtt
650	12	\|aEnzyme Inhibitors\|xtherapeutic use.
650	22	\|aDrug Design.
650	22	\|aEnzyme Inhibitors\|xchemistry.
650	6	\|aAntienzymes\|xEmploi en therapeutique\|xTests.
650	6	\|aMedicaments\|xConception.
650	6	\|aAntienzymes\|xRelations structure-activite.
856	42	\|3Contributor biographical information\|uhttp://www.loc.gov/catdir/enhancements/fy0617/2004023470-b.html
856	41	\|zAvailable to Stanford-affiliated users at:\|uhttp://site.ebrary.com/lib/stanford/Doc?id=10114176\|xeLoaderURL\|xeb4\|xebebr10114176
910		\|a20081224